Journal of Dermatology Study and Treatment

Short Communication

Varicella Zoster Virus Detection from the Crust using by Derma Quick® VZV

Makoto Kondo, Ayuko Kobayasi and Keiichi Yamanaka*

Department of Dermatology, Graduate School of Medicine, Mie University, Japan

Received: 08 December 2018

Accepted: 15 December 2018

Version of Record Online: 18 December 2018

Citation

Kondo M, Kobayasi A, Yamanaka K (2018) Varicella Zoster Virus Detection from the Crust using by Derma Quick® VZV. J Dermatol Stud Treat 2018(1): 10-11.

Correspondence should be addressed to

Keiichi Yamanaka, Japan

E-mail: yamake@clin.medic.mie-u.ac.jp

DOI: 10.33513/JDST/1801-03

Copyright

Copyright © 2018 Makoto Kondo et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and work is properly cited.

Keywords: Crust; Derma Quick® VZV; Herpes Zoster Virus; Immunochromatography


Abbreviation

HSV    : Herpes Simplex Virus
HZ      : Herpes Zoster
VZV   : Varicella Zoster Virus

Herpes Zoster (HZ) is induced by the reactivation of Varicella Zoster Virus (VZV) infected latently in the nerve ganglion. Initially HZ patients feel a superficial pain at the nerve region of VZV reactivation. And then a band like erythema appears around the nerve-dominant region and gradually changes from blister to crust. Dermatologists often diagnose by the patient’s painful symptom and characteristic eruption. Skilful doctors also make a diagnosis by the detection of giant cells from the blister.

Derma Quick® VZV, the detection kit for VZV using easy and quick immunochromatography, is recently released and commercially available [1]. The kit is composed of fixed anti-VZV monoclonal antibody on the cartridge and possible to detect VZV antigen rapidly in 5 to 10 minutes. The recommended sample for this kit is bulla content from HZ, and has a sensitivity of 93.2% and a specificity of 98.8% for VZV, showing no cross-reactivity with Herpes Simplex Virus (HSV)-1 and HSV-2.1 Dermatologist diagnoses HZ without any difficulty because HZ shows typical clinical phenotypes. The current kit will contribute mainly to the hospital without dermatologist. We here reported new finding and how to use it for non-dermatologist physicians as rapid diagnosis in patient with severe erythema, erosion, and eschar; resembling to trauma with haemorrhage or in patient with difficulty of communication, resulting in the delay of diagnosis. For this reason, we investigated VZV antigen from the crust using Derma Quick® VZV. We succeeded in the detection of VZV antigen from crust (Figure 1). Surprisingly, VZV antigen was still positive from the crust in patient after taking anti-HZ drug for seven days. Therefore, the kit will help the definite diagnosis of a patient with multiple atypical crust for dermatologists as well as non-dermatologist physicians.

Varicella-Zoster-Virus-Detection-from-the-Crust-using-by-Derma-Quick-VZV

Case

1

2

3

4

5

6

Age

76

70

73

52

84

79

Sex

F

M

F

F

M

F

Past history

Diabetes, Cerebral Infarction

Diabetes, Cardiac Infarction

Dermatomyositis

None

Dementia

Hypertension

First consulted day from onset

Unknown

3

3

13

Unknown

4

Days of taking anti-HZ drug

4 Days

7 Days

7 Days

7 Days

None

6 days

The kind of used drug

Aciclovir

Famciclovir

Famciclovir

Valaciclovir

none

Valaciclovir

Previous history of HZ

0

0

0

3

Unknown

0

The day performed test from crust after onset /result

7 day/+

7 day/+

14 day/-

14 day/-

Unknown/-

12 day/+

Figure 1: The summary of HZ patients using this kit. Typical two cases of patient’s history infected HZ and figures after taking anti-HZ drug are also presented.

Grant Support: The authors did not receive any financial support for the present study.

Competing Interest: The authors have declared that no competing interests exist.

References

  1. Maruho Co Ltd (2018) Maruho Launches In vitro Diagnostic “Derma Quick® VZV”. Maruho, Japan 2018: 01-02.
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